2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Base Information

Chemical Name:2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane
CAS No.:165557-43-7
Molecular Formula:C₁₅H₂₁N₃O₂
Molecular Weight:275.351
Hs Code.:

Synonyms:2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

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Technology Process of 2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

There total 6 articles about 2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 165879-49-2
2-Methoxycarbonyl-3-phenyl-1,3-diazabicyclo<3.3.0>octane

: 165557-43-7
2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Guidance literature:: With trimethylaluminum;
DOI:10.1016/0040-4039(95)00334-9

Reference yield:

: 64030-42-8
benzyl (2S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

: 165557-43-7
2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / 10percent Pd/C / methanol / 5 h / Ambient temperature

2: 78 percent / LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

3: 95 percent / toluene / 0.25 h / Ambient temperature

4: 81 percent / Me₃Al / tetrahydrofuran; hexane / 1.) r.t., 1 h, 2.) r.t., 60 h

With lithium aluminium tetrahydride; hydrogen; trimethylaluminum; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; toluene;
DOI:10.1039/P19960002117

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 165557-43-7
2-(N-Methoxy-N-methylaminocarbonyl)-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / aq. NaHCO₃ / toluene / 5 h / Ambient temperature

2: 1.) N-methylmorpholine, EtOCOCl

3: 90 percent / H₂ / 10percent Pd/C / methanol / 5 h / Ambient temperature

4: 78 percent / LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

5: 95 percent / toluene / 0.25 h / Ambient temperature

6: 81 percent / Me₃Al / tetrahydrofuran; hexane / 1.) r.t., 1 h, 2.) r.t., 60 h

With 4-methyl-morpholine; lithium aluminium tetrahydride; hydrogen; trimethylaluminum; chloroformic acid ethyl ester; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; toluene;
DOI:10.1039/P19960002117