({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester

Base Information

• Chemical Name: ({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester
• CAS No.: 444579-08-2
• Molecular Formula: C₃₃H₄₁N₂O₁₂P₃
• Molecular Weight: 750.616
• Mol file: 444579-08-2.mol

Synonyms:({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester

Chemical Property of ({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester

There total 2 articles about ({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-(3-Bromomethylphenyl)phthalimide (129747-78-0) + 3,5-bis-(dimethoxyphosphorylmethyl)benzoic acid diethoxyphosphorylmethylamide (367927-29-5) → ({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester (444579-08-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol025976q

Reference yield:

5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester (223449-19-2) → ({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester (444579-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / T₃P; NMM

2: 62 percent / sodium hydride / dimethylformamide

With 4-methyl-morpholine; 2-propane phosphonic acid anhydride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol025976q

Reference yield: 61.0%

({[3,5-bis-(dimethoxy-phosphorylmethyl)-benzoyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzyl]-amino}-methyl)-phosphonic acid diethyl ester (444579-08-2) → C29H30N2O12P3(3-)

Guidance literature:

With lithium bromide;

DOI:10.1021/ol025976q

upstream raw materials:

N-(3-Bromomethylphenyl)phthalimide

3,5-bis-(dimethoxyphosphorylmethyl)benzoic acid diethoxyphosphorylmethylamide

5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester