3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene

Base Information

• Chemical Name: 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene
• CAS No.: 90850-50-3
• Molecular Formula: C₃₂H₂₂F₁₄O₂
• Molecular Weight: 704.503
• Mol file: 90850-50-3.mol

Synonyms:3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene

Chemical Property of 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene

There total 1 articles about 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

estradiol (50-28-2) + perfluorotoluene (434-64-0) → 3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-17β-ol (90850-46-7) + 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene (90850-50-3)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1039/c39840000125

Reference yield: 88.0%

3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene (90850-50-3) → 3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-17β-ol (90850-46-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.25h; Ambient temperature;

Reference yield: 78.0%

sodium methylate (124-41-4) + 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene (90850-50-3) → 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol (90850-54-7)

Guidance literature:

In N,N-dimethyl-formamide; at 10 ℃; for 1h;

DOI:10.1039/c39840000125

upstream raw materials:

estradiol

perfluorotoluene

Downstream raw materials:

estradiol

17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol

3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-17β-ol

3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-17-one