Technology Process of 1-(2-chloromethyloxazol-5-yl)-2,5-dimethoxy-3,4,6-trimethylbenzene
There total 7 articles about 1-(2-chloromethyloxazol-5-yl)-2,5-dimethoxy-3,4,6-trimethylbenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride; triethylamine;
In
dichloromethane;
for 1h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / K2CO3 / acetone / 24 h / Heating
2: 73 percent / trifluoroacetic acid / 24 h / Heating
3: K2CO3 / methanol / 24 h / Ambient temperature
4: 72 percent / Amberlyst 15, mol. sieves 4 Angstroem / CH2Cl2 / 120 h / Heating
5: 1.) n-BuLi, LiBr / 1.) THF, hexane, -78 deg C, 30 min, 2.) from -78 deg C to RT
6: 94 percent / sodium borohydride / methanol / 0.5 h
7: 88 percent / thionyl chloride, triethylamine / CH2Cl2 / 1 h / Ambient temperature
With
sodium tetrahydroborate; n-butyllithium; thionyl chloride; Amberlyst 15; 4 A molecular sieve; potassium carbonate; triethylamine; trifluoroacetic acid; lithium bromide;
In
methanol; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 73 percent / trifluoroacetic acid / 24 h / Heating
2: K2CO3 / methanol / 24 h / Ambient temperature
3: 72 percent / Amberlyst 15, mol. sieves 4 Angstroem / CH2Cl2 / 120 h / Heating
4: 1.) n-BuLi, LiBr / 1.) THF, hexane, -78 deg C, 30 min, 2.) from -78 deg C to RT
5: 94 percent / sodium borohydride / methanol / 0.5 h
6: 88 percent / thionyl chloride, triethylamine / CH2Cl2 / 1 h / Ambient temperature
With
sodium tetrahydroborate; n-butyllithium; thionyl chloride; Amberlyst 15; 4 A molecular sieve; potassium carbonate; triethylamine; trifluoroacetic acid; lithium bromide;
In
methanol; dichloromethane;
