3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

Base Information

Chemical Name:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide
CAS No.:921629-60-9
Molecular Formula:C₃₇H₄₈Cl₂N₂O₅S
Molecular Weight:703.771
Hs Code.:

Synonyms:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

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Chemical Property of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

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Technology Process of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

There total 16 articles about 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056555-24-8
tert-butyl (3-[(cyclopropyl)[3-(3-methoxypropyl)-5-[3-(methylthio)propoxy]benzyl]amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

: 921629-60-9
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1026786-84-4
3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde

: 921629-60-9
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: magnesium sulfate / dichloromethane / 12 h / 20 °C

2.2: 3 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

7.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1026786-89-9
[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{(1E)-3-methoxyprop-1-en-1-yl}benzyl)amino]cyclopropane

: 921629-60-9
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-{3-(3-methoxypropyl)-5-[(3-methylthio)propoxy]benzyl}propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

5: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;