4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-BUT-2-YNOIC ACID

Base Information

• Chemical Name: 4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-BUT-2-YNOIC ACID
• CAS No.: 102245-65-8
• Molecular Formula: C10H18 O3 Si
• Molecular Weight: 214.337
• Mol file: 102245-65-8.mol

Synonyms:4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-BUT-2-YNOIC ACID;4-(TERT-BUTYLDIMETHYLSILYLOXY)-2-BUTYNOIC ACID;4-(Tert-Butyldimethylsilanyloxy)but-2-ylnoicacid

Chemical Property of 4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-BUT-2-YNOIC ACID

Chemical Property:

• Boiling Point: 268.1±23.0 °C(Predicted)
• PKA: 2.04±0.10(Predicted)
• PSA: 46.53000
• Density: 1.003±0.06 g/cm3(Predicted)
• LogP: 2.09620

Purity/Quality:

98%Min ^*data from raw suppliers

4-(tert-Butyldimethylsilyloxy)-2-butynoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-BUT-2-YNOIC ACID

There total 3 articles about 4-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-BUT-2-YNOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + tert-Butyldimethyl(prop-2-ynyloxy)silane (76782-82-6) → 4-[Dimethyl(1,1-dimethylethyl)silyloxy]-2-butynoic acid (102245-65-8)

Guidance literature:

tert-Butyldimethyl(prop-2-ynyloxy)silane; With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 4h;

carbon dioxide; In tetrahydrofuran; diethyl ether; Further stages.;

DOI:10.1021/jm0005555

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4-[Dimethyl(1,1-dimethylethyl)silyloxy]-2-butynoic acid (102245-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 64 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 21 h / 20 °C

2.1: MeMgBr / tetrahydrofuran; diethyl ether / 4 h / 0 - 20 °C

2.2: 6.28 g / tetrahydrofuran; diethyl ether

With dmap; methylmagnesium bromide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jm0005555

Reference yield:

→ 4-[Dimethyl(1,1-dimethylethyl)silyloxy]-2-butynoic acid (102245-65-8)

Guidance literature:

upstream raw materials:

carbon dioxide

tert-Butyldimethyl(prop-2-ynyloxy)silane

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]-4-(tert-butyl-dimethyl-silanyloxy)-2-butynamide

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