Technology Process of 4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid
There total 5 articles about 4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
t-butyldimethylsiyl triflate; sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate;
With
2,6-dimethylpyridine;
In
dichloromethane;
at 20 ℃;
for 5h;
With
pyridine hydrochloride;
In
methanol; water;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 23 h
2.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C
3.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.25 h / 20 °C
3.2: 1 h / 20 °C
4.1: sodium hydroxide / ethanol / 2 h / 20 °C
5.1: 2,6-dimethylpyridine / dichloromethane / 5 h / 20 °C
5.2: 2 h / 20 °C
With
2,6-dimethylpyridine; 18-crown-6 ether; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydroxide;
In
tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.25 h / 20 °C
1.2: 1 h / 20 °C
2.1: sodium hydroxide / ethanol / 2 h / 20 °C
3.1: 2,6-dimethylpyridine / dichloromethane / 5 h / 20 °C
3.2: 2 h / 20 °C
With
2,6-dimethylpyridine; 18-crown-6 ether; potassium tert-butylate; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane;
