4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

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Chemical Name:4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid
CAS No.:1614252-00-4
Molecular Formula:C₂₅H₃₄FN₃O₅Si
Molecular Weight:503.646
Hs Code.:

Synonyms:4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

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Chemical Property of 4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

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Technology Process of 4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

There total 5 articles about 4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1614251-99-8
sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

: 1614252-00-4
4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

Guidance literature:: t-butyldimethylsiyl triflate; sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate; With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 5h;

With pyridine hydrochloride; In methanol; water; at 20 ℃; for 2h;

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 1614252-00-4
4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 23 h

2.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C

3.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.25 h / 20 °C

3.2: 1 h / 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 20 °C

5.1: 2,6-dimethylpyridine / dichloromethane / 5 h / 20 °C

5.2: 2 h / 20 °C

With 2,6-dimethylpyridine; 18-crown-6 ether; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1614251-97-6
(5-oxotetrahydrofuran-3-yl)methyl trifluoromethanesulfonate

: 1614252-00-4
4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.25 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydroxide / ethanol / 2 h / 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 5 h / 20 °C

3.2: 2 h / 20 °C

With 2,6-dimethylpyridine; 18-crown-6 ether; potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;