sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

Base Information

• Chemical Name: sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate
• CAS No.: 1614251-99-8
• Molecular Formula: C₁₉H₁₉FN₃O₅*Na
• Molecular Weight: 411.365
• Mol file: 1614251-99-8.mol

Synonyms:sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

Chemical Property of sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate

There total 4 articles about sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3-fluorophenyl)-1,3-dimethyl-6-((5-oxotetrahydrofuran-3-yl)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1614251-98-7) → sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate (1614251-99-8)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 2h;

Reference yield:

4-hydroxymethyl-5H-furan-2-one (80904-75-2) → sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate (1614251-99-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 23 h

2.1: 2,6-dimethylpyridine / dichloromethane / 0.33 h / 0 °C

3.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.25 h / 20 °C

3.2: 1 h / 20 °C

4.1: sodium hydroxide / ethanol / 2 h / 20 °C

With 2,6-dimethylpyridine; 18-crown-6 ether; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane;

Reference yield:

(5-oxotetrahydrofuran-3-yl)methyl trifluoromethanesulfonate (1614251-97-6) → sodium 4-(5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-3-(hydroxymethyl)butanoate (1614251-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.25 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydroxide / ethanol / 2 h / 20 °C

With 18-crown-6 ether; potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; ethanol;

upstream raw materials:

4-hydroxymethyl-5H-furan-2-one

4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one

(5-oxotetrahydrofuran-3-yl)methyl trifluoromethanesulfonate

5-(3-fluorophenyl)-1,3-dimethyl-6-((5-oxotetrahydrofuran-3-yl)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Downstream raw materials:

4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)-N-methoxy-N-methylbutanamide

6-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(4-chlorothiazol-2-yl)-4-oxobutyl)-5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

10-(4-chlorothiazol-2-yl)-5-(3-fluorophenyl)-8-(hydroxymethyl)-1,3-dimethyl-7,8-dihydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

4-((tert-butyldimethylsilyl)oxy)-3-((5-(3-fluorophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)methyl)butanoic acid