2-Ethyl-7-methoxybenzofuran

Base Information

• Chemical Name: 2-Ethyl-7-methoxybenzofuran
• CAS No.: 102234-44-6
• Molecular Formula: C11H12 O2
• Molecular Weight: 176.21178
• DSSTox Substance ID: DTXSID80407876
• Nikkaji Number: J985.942J
• Wikidata: Q82213224
• Mol file: 102234-44-6.mol

Synonyms:2-ETHYL-7-METHOXYBENZOFURAN;2-ethyl-7-methoxy-1-benzofuran;102234-44-6;2-Ethyl-7-methoxybenzofuran, 97per cent;SCHEMBL348215;DTXSID80407876;WWEPPXYVWNVLGW-UHFFFAOYSA-N;2-Ethyl-7-methoxybenzofuran,97%;AKOS006228862

Chemical Property of 2-Ethyl-7-methoxybenzofuran

Chemical Property:

• PSA: 22.37000
• LogP: 3.00380
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

2-ETHYL-7-METHOXYBENZOFURAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC2=C(O1)C(=CC=C2)OC

Technology Process of 2-Ethyl-7-methoxybenzofuran

There total 12 articles about 2-Ethyl-7-methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-Acetyl-7-methoxybenzofuran (43071-52-9) → 2-ethyl-7-methoxybenzo[b]furan (102234-44-6)

Guidance literature:

2-Acetyl-7-methoxybenzofuran; With hydrazine; In water; diethylene glycol; at 120 - 190 ℃;

With potassium hydroxide; In water; diethylene glycol; at 120 - 130 ℃; for 6h;

DOI:10.1021/jm1015022

Reference yield: 91.0%

→ 2-ethyl-7-methoxybenzo[b]furan (102234-44-6)

Guidance literature:

Reference yield: 80.0%

7-Methoxy-2-(1-methoxy-ethyl)-benzofuran → 2-ethyl-7-methoxybenzo[b]furan (102234-44-6)

Guidance literature:

With chloro-trimethyl-silane; 3 A molecular sieve; sodium cyanoborohydride; In acetonitrile; for 24h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01519-6

upstream raw materials:

2-Acetyl-7-methoxybenzofuran

3-methoxy-2-hydroxybenzaldehyde

2-(2-formyl-6-methoxyphenoxy)butanoic acid

acetic anhydride

Downstream raw materials:

(2-ethyl-7-hydroxybenzofuran-3-yl)(4-methoxyphenyl)methanone

(2-ethyl-7-hydroxybenzofuran-4-yl)(4-methoxyphenyl)methanone

(2-ethyl-7-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone

(6-bromo-2-ethyl-7-hydroxybenzofuran-4-yl)(3,5-dibromo-4-hydroxyphenyl)methanone

Refernces

• 1、 -. "DEVELOPING POTENT URATE TRANSPORTER INHIBITORS: COMPOUNDS DESIGNED FOR THEIR URICOSURIC ACTION". Page/Page column 14. . Retrieved 2012/04/23.
• 2、 Kowalewska, Monika,Kwiecień, Halina. "A new course of the Perkin cyclization of 2-(2-formyl-6-methoxyphenoxy)alkanoic acids. Synthesis of 2-alkyl-7-methoxy-5-nitrobenzo[b]furans". . p. 5085 - 5090. Retrieved 2008/09/21.