4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

Base Information

Chemical Name:4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine
CAS No.:833468-70-5
Molecular Formula:C₂₃H₂₂ClF₄N₅
Molecular Weight:479.908
Hs Code.:

Synonyms:4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

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Chemical Property of 4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

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Technology Process of 4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

There total 4 articles about 4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-chloro-6-(3-chloro-4-fluorophenyl)-2-isopropyl-pyrimidine

: 87394-63-6
1-(3-trifluoromethylpyridin-2-yl)piperazine

: 833468-70-5
4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

Guidance literature:: With potassium carbonate; In ISOPROPYLAMIDE; at 120 ℃; for 18h;

Reference yield:

: 72835-76-8
3-(3-chloro-4-fluoro-phenyl)-3-oxo-propionic acid ethyl ester

: 833468-70-5
4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 20 h / 20 °C

2: trichlorophosphate / 4 h / 100 °C

3: potassium carbonate / ISOPROPYLAMIDE / 18 h / 120 °C

With potassium carbonate; trichlorophosphate; In ISOPROPYLAMIDE; toluene;

Reference yield:

: 6-(3-chloro-4-fluorophenyl)-2-isopropylpyrimidin-4-ol

: 833468-70-5
4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 4 h / 100 °C

2: potassium carbonate / ISOPROPYLAMIDE / 18 h / 120 °C

With potassium carbonate; trichlorophosphate; In ISOPROPYLAMIDE;