2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide

Base Information

• Chemical Name: 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide
• CAS No.: 145006-28-6
• Molecular Formula: C₁₅H₁₂BrNO₃S
• Molecular Weight: 366.235
• Mol file: 145006-28-6.mol

Synonyms:2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide

Chemical Property of 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide

There total 3 articles about 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester (145006-90-2) → 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide (145006-28-6)

Guidance literature:

With pyridine; dmap; In xylene; for 25h; Heating;

DOI:10.1021/jm00102a016

Reference yield:

4-Bromophenethylamine (73918-56-6) → 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide (145006-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridine / CHCl₃ / Ambient temperature

2: 78 percent / 4-(dimethylamino)pyridine, pyridine / xylene / 25 h / Heating

With pyridine; dmap; In chloroform; xylene;

DOI:10.1021/jm00102a016

Reference yield:

2-methoxycarbonylbenzenesulfonyl chloride (26638-43-7) → 2-<2-(4-bromophenyl)ethyl>benzisothiazolin-3-one 1,1-dioxide (145006-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridine / CHCl₃ / Ambient temperature

2: 78 percent / 4-(dimethylamino)pyridine, pyridine / xylene / 25 h / Heating

With pyridine; dmap; In chloroform; xylene;

DOI:10.1021/jm00102a016

upstream raw materials:

2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-benzoic acid methyl ester

4-Bromophenethylamine

2-methoxycarbonylbenzenesulfonyl chloride

Downstream raw materials:

{2-[2-(4-Bromo-phenyl)-ethyl]-3-cyano-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[d]isothiazol-3-yl}-cyano-acetic acid ethyl ester

C₂₀H₁₇BrN₂O₆S

3-{2-[2-(4-Bromo-phenyl)-ethylsulfamoyl]-phenyl}-2-cyano-3-oxo-propionic acid ethyl ester