Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin

Base Information

• Chemical Name: Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin
• CAS No.: 1313026-32-2
• Molecular Formula: C₂₇H₃₅N₁₁O₈
• Molecular Weight: 641.644

Synonyms:Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin

Chemical Property of Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin

Chemical Property:

• Melting Point: 205 °C (decomp)

Purity/Quality:

97% ^*data from raw suppliers

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Technology Process of Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin

There total 11 articles about Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

C31H43N11O8 (1391826-59-7) → Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}pteroyl-L-glutamin (1313026-32-2)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 3h;

DOI:10.1021/ja303251f

Reference yield: 28.0%

2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine (134179-38-7) + folate (59-30-3) → 16-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-azido-13-oxo-3,6,9-trioxa-12-azaheptadecan-17-oic acid (1313026-32-2)

Guidance literature:

folate; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃;

2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine; With dmap; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1002/asia.201801396

Reference yield:

(S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxopentanoic acid (153445-05-7) + 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethylamine (134179-38-7) → (S)-16-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)-1-azido-13-oxo-3,6,9-trioxa-12-azaheptadecan-17-oic acid (1313026-32-2)

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 12h;

upstream raw materials:

Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}-α-(tertbutyl)-Nα-Fmoc-L-glutamin

Nγ-{{[(azidoethoxy)ethoxy]ethoxy}ethyl}-α-(tertbutyl)-L-glutamin

C₃₁H₄₃N₁₁O₈

Fmoc-Glu-OtBu

Downstream raw materials:

18-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)-1-(1-(1-(3-(5-(benzylamino)-5-oxopent-1-yn-1-yl)-4-methoxyphenyl)-1,1-bis(4-methoxyphenyl)-5-oxo-10,13,16-trioxa-2-thia-6-azanonadecan-19-yl)-4-fluoro-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazol-4-yl)-1,15-dioxo-5,8,11-trioxa-2,14-diazanonadecan-19-oic acid

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