153445-05-7

Upstream product

• 59-30-3 folic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 59-30-3 folate 
• 59-30-3 (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid 
• 538-75-0 dicyclohexyl-carbodiimide 

Downstream Products

• 1041170-97-1 C₇₃H₇₉N₉O₂₃S₂ 
• 1246993-53-2 C₃₄H₄₅N₉O₉ 
• 197151-85-2 N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine 
• 197151-85-2 folate-γ-ethylenediamine 
• 1300726-25-3 folate-GpYK-Taxol 
• 819074-44-7 C₂₉H₄₁N₉O₈ 
• 1334524-29-6 C₅₀H₅₆N₉O₁₁P 
• 1043923-82-5 C₃₄H₄₉N₉O₁₀ 
• 1227374-40-4 C₄₅H₄₇N₁₉O₁₂S₂ 
• 1099829-16-9 FA-propaneamine 
• 1313026-32-2 (S)-16-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)-1-azido-13-oxo-3,6,9-trioxa-12-azaheptadecan-17-oic acid 
• 250143-83-0 N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-((R)-1-carboxy-2-mercaptoethyl)-L-glutamine 

Relevant academic research and scientific papers

Quinoxaline-based polymer dots with ultrabright red to near-infrared fluorescence for in vivo biological imaging

This article describes the design and synthesis of quinoxaline-based semiconducting polymer dots (Pdots) that exhibit near-infrared fluorescence, ultrahigh brightness, large Stokes shifts, and excellent cellular targeting capability. We also introduced fluorine atoms and long alkyl chains into polymer backbones and systematically investigated their effect on the fluorescence quantum yields of Pdots. These new series of quinoxaline-based Pdots have a fluorescence quantum yield as high as 47% with a Stokes shift larger than 150 nm. Single-particle analysis reveals that the average per-particle brightness of the Pdots is at least 6 times higher than that of the commercially available quantum dots. We further demonstrated the use of this new class of quinoxaline-based Pdots for effective and specific cellular and subcellular labeling without any noticeable nonspecific binding. Moreover, the cytotoxicity of Pdots were evaluated on HeLa cells and zebrafish embryos to demonstrate their great biocompatibility. By taking advantage of their extreme brightness and minimal cytotoxicity, we performed, for the first time, in vivo microangiography imaging on living zebrafish embryos using Pdots. These quinoxaline-based NIR-fluorescent Pdots are anticipated to find broad use in a variety of in vitro and in vivo biological research.

The targeting behavior of folate-nanohydrogel evaluated by near infrared imaging system in tumor-bearing mouse model

Purpose: To synthesize P[(Folate-Allylamine)-co-(N-isopropylacrylamine)- co-Acrylamide] (P(FoAAn-co-NIPA-AAm), folate-NHG) with appropriate diameter and lower critical solution temperature (LCST) for targeting to folate receptor (FR) expressing tumors. Me

Antiangiogenic and apoptotic properties of a novel amphiphilic folate-heparin-lithocholate derivative having cellular internality for cancer therapy

Purpose. Anitangiogenic and apoptotic properties of a novel chemically modified heparin derivative with low anticoagulant activity were evaluated on the experimental in vitro and in vivo model. Materials and Methods. Heparin-lithocholate conjugate (HL) wa

A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

A new folate-conjugated platinum porphyrin complex (Por 4) was synthesized and characterized. The singlet oxygen production of the conjugates was evaluated through a 1,3-diphenylisobenzofuran method. The targeting ability and subcellular localization of P

Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates

Three conjugates based on dendrimer PAMAM generation five were synthesized and radiolabeled successfully. To investigate their tumor targeting, the in vitro and in vivo stability, cell uptake, in vivo biodistribution, and micro-SPECT imaging were evaluate

Design of folic acid decorated virus-mimicking nanoparticles for enhanced oral insulin delivery

Mucus penetration and intestinal cells targeting are two main strategies to improve insulin oral delivery efficiency. However, few studies are available regarding the effectiveness of combining these two strategies into one nano-delivery system. For this

Development of 153Sm-folate-polyethyleneimine-conjugated chitosan nanoparticles for targeted therapy

The aim of this study was to develop biocompatible, water-soluble 153Sm-labeled chitosan nanoparticles (NPs) containing folate and polyethyleneimine functionalities i.e. chitosan-graft-PEI-folate (CHI-DTPA-g-PEI-FA), suitable for targeted thera

Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo

LDL particles are high-capacity nanocarriers with precisely controlled size and are naturally biocompatible, biodegradable, and nonimmunogenic. However, their utilities as drug carriers are limited by the narrow purview of LDL receptor-positive tumors. Here, we synthsized a ligand-conjugated, NIR-labeled LDL that enables the first in vivo demonstration of rerouting LDL from LDL receptors to selected alternate receptors, thus drastically expanding the range of using LDL particles as nanocarriers for in vivo cancer imaging and treatment. Copyright

Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive

A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-β- cyclodextrin (CDEnFA) with high yield (60 %). Elemental analysis, mass spectrometry, 1H and 13C NMR,

Folic acid modified superparamagnetic iron oxide nanocomposites for targeted hepatic carcinoma MR imaging

A novel targeted MRI contrast agent for tumor cells and tumor over-expressing affinity receptor was synthesized and characterized. Dopamine (DA) was used to present functional molecules on the surface of superparamagnetic iron oxide nanoparticles (SPIONs)