9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

Base Information

Chemical Name:9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine
CAS No.:1420353-42-9
Molecular Formula:C₂₀H₂₂N₈O₄
Molecular Weight:438.446
Hs Code.:

Synonyms:9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

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Chemical Property of 9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

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Technology Process of 9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

There total 3 articles about 9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1420352-98-2
9-(2’,3’,4’-tri-O-acetyl-α-D-arabinopyranosyl)-2,6-bis-(4-phenyl-1H-1,2,3-triazol-1-yl)-9H-purine

: 124-40-3
dimethyl amine

: 1420353-42-9
9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

Guidance literature:: In tetrahydrofuran; at 40 ℃; for 4h;
DOI:10.1016/j.tetlet.2012.11.095

Reference yield:

: 2,6-diazidopurine

: 1420353-42-9
9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 40 °C

1.2: 75 - 80 °C

2.1: copper(ll) sulfate pentahydrate; acetic acid; sodium L-ascorbate / water; tert-butyl alcohol; acetone / 3.5 h / 20 °C

3.1: tetrahydrofuran / 4 h / 40 °C

With N,O-bis-(trimethylsilyl)-acetamide; copper(ll) sulfate pentahydrate; acetic acid; sodium L-ascorbate; In tetrahydrofuran; water; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.11.095

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 1420353-42-9
9-(α-D-arabinopyranosyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-6-dimethylamino-9H-purine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / ethanol / 0.08 h / Reflux

2.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 40 °C

2.2: 75 - 80 °C

3.1: copper(ll) sulfate pentahydrate; acetic acid; sodium L-ascorbate / water; tert-butyl alcohol; acetone / 3.5 h / 20 °C

4.1: tetrahydrofuran / 4 h / 40 °C

With sodium azide; N,O-bis-(trimethylsilyl)-acetamide; copper(ll) sulfate pentahydrate; acetic acid; sodium L-ascorbate; In tetrahydrofuran; ethanol; water; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.11.095