N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Base Information

Chemical Name:N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide
CAS No.:1622096-31-4
Molecular Formula:C₃₁H₄₅NO₇SSi
Molecular Weight:603.852
Hs Code.:

Synonyms:N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

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Chemical Property of N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

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Technology Process of N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

There total 13 articles about N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: N-(2-((5S,6R)-5-((tert-butyldimethylsilyl)oxy)-6-hydroxycyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

: 65299-00-5
3-hydroxy-4-(methoxymethoxy)benzaldehyde

: 1622096-31-4
N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; at -10 - 20 ℃; for 22h;
DOI:10.1002/anie.201400286

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1622096-31-4
N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3: potassium carbonate; methanol / 0.67 h / 20 °C

4: tributylphosphine; diamide / tetrahydrofuran / 22 h / -10 - 20 °C

With methanol; tributylphosphine; diamide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 4: |Mitsunobu Displacement;
DOI:10.1002/anie.201400286

Reference yield:

: 65298-95-5
3-Acetoxy-4-(methoxymethoxy)benzaldehyd

: 1622096-31-4
N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; methanol / 0.67 h / 20 °C

2: tributylphosphine; diamide / tetrahydrofuran / 22 h / -10 - 20 °C

With methanol; tributylphosphine; diamide; potassium carbonate; In tetrahydrofuran; 2: |Mitsunobu Displacement;
DOI:10.1002/anie.201400286