2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

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Chemical Name:2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane
CAS No.:1416175-40-0
Molecular Formula:C₂₄H₃₂N₂O₃S
Molecular Weight:428.596
Hs Code.:

Synonyms:2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

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Chemical Property of 2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

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Technology Process of 2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

There total 8 articles about 2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3510-66-5
2-Bromo-5-methylpyridine

: 2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-azaspiro[3.5]nonane

: 1416175-40-0
2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In 1,2-dimethoxyethane; at 60 ℃; for 9h;
DOI:10.1016/j.bmc.2018.02.032

Reference yield:

: 203661-69-2
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

: 1416175-40-0
2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / toluene / 0.33 h / 20 °C / Inert atmosphere

1.2: 4 h / 70 °C / Inert atmosphere

2.1: trifluoroacetic acid / acetonitrile; water / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.33 h / Cooling with ice

3.2: 3 h / 20 °C

4.1: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 °C

6.1: diamide; tributylphosphine / tetrahydrofuran / 60 °C

7.1: hydrogenchloride / ethyl acetate / 20 °C

8.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxyethane / 9 h / 60 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributylphosphine; diamide; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; sodium hydride; diisobutylaluminium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination / 6.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2018.02.032

Reference yield:

: tert-butyl 2-(methoxymethylidene)-7-azaspiro[3.5]nonane-7-carboxylate

: 1416175-40-0
2-{3-[4-(methanesulfonyl)phenoxy]propyl}-7-(5-methylpyridin-2-yl)-7-azaspiro[3.5]nonane

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / acetonitrile; water / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.33 h / Cooling with ice

2.2: 3 h / 20 °C

3.1: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 °C

5.1: diamide; tributylphosphine / tetrahydrofuran / 60 °C

6.1: hydrogenchloride / ethyl acetate / 20 °C

7.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxyethane / 9 h / 60 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tributylphosphine; diamide; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; diisobutylaluminium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination / 5.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2018.02.032