ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

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Chemical Name:ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate
CAS No.:1354041-60-3
Molecular Formula:C₂₀H₁₇FN₆O₃
Molecular Weight:408.392
Hs Code.:

Synonyms:ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

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Chemical Property of ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

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Technology Process of ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

There total 3 articles about ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 64-17-5
ethanol

: 1354041-59-0
C₁₈H₁₂FN₇O

: 1354041-60-3
ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 24h;

Reference yield: 4.0%

: 144918-37-6,56569-41-6
1-cyano-1-ethoxycarbonyl-1-butene

: 1354044-23-7
1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide

: 1354041-38-5
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-4-hydroxypyrimidine-5-carbonitrile

: 1354041-60-3
ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 80 ℃; for 24h;
DOI:10.1021/acsmedchemlett.5b00479

Reference yield:

: 1354044-05-5
1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride

: 1354041-38-5
2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)-4-hydroxypyrimidine-5-carbonitrile

: 1354041-60-3
ethyl 4-amino-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; trimethylaluminum / toluene / 16 h / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 24 h / 80 °C

With trimethylaluminum; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; toluene;
DOI:10.1021/acsmedchemlett.5b00479