5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

Base Information

Chemical Name:5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine
CAS No.:179483-00-2
Molecular Formula:C₂₀H₁₈F₂N₂O₂
Molecular Weight:356.372
Hs Code.:

Synonyms:5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

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Chemical Property of 5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

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Technology Process of 5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

There total 4 articles about 5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 124-42-5
acetamidine hydrochloride

: benzyl 3-oxo-2-(2,4-difluorobenzylidenyl)butanoate

: 179483-00-2
5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

Guidance literature:: acetamidine hydrochloride; benzyl 3-oxo-2-(2,4-difluorobenzylidenyl)butanoate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 100 - 120 ℃; for 2h;
DOI:10.1021/jm9902032

Reference yield: 42.0%

: 179483-00-2
5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

Guidance literature:

Reference yield:

: 5396-89-4
benzyl acetoacetate

: 179483-00-2
5-benzyloxycarbonyl-6-(2,4-difluorophenyl)-1,6-dihydro-2,4-dimethylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / acetic acid; piperidine / propan-2-ol / 48 h / 20 °C

2.1: t-BuOK / dimethylformamide / 0.25 h / 0 °C

2.2: 42 percent / p-TsOH*H₂O / dimethylformamide / 2 h / 100 - 120 °C

With piperidine; potassium tert-butylate; acetic acid; In N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Condensation / 2.1: Cycloaddition / 2.2: Dehydration;
DOI:10.1021/jm9902032