3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one

Base Information

• Chemical Name: 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one
• CAS No.: 204245-67-0
• Molecular Formula: C₁₉H₂₉N₃O
• Molecular Weight: 315.459
• Mol file: 204245-67-0.mol

Synonyms:3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one

Chemical Property of 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one

There total 6 articles about 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

{4-[3-Oxo-3-(4-phenyl-piperazin-1-yl)-propyl]-cyclohexyl}-carbamic acid tert-butyl ester (204245-66-9) → 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one (204245-67-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 16h; Ambient temperature;

DOI:10.1021/jm9707378

Reference yield:

4-nitro-trans-cinnamic acid (882-06-4) → 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one (204245-67-0)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂, aq. NaOH / Ru/C / 17 h / 100 °C / 103430 Torr

2: tetrahydrofuran; H₂O / 16 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: CH₂Cl₂ / 18 h / 0 - 20 °C

5: 96 percent / TFA / CHCl₃ / 16 h / Ambient temperature

With sodium hydroxide; hydrogen; triethylamine; trifluoroacetic acid; Ru-carbon; In tetrahydrofuran; dichloromethane; chloroform; water;

DOI:10.1021/jm9707378

Reference yield:

4-phenyl-1-piperazine (92-54-6) → 3-(4-Amino-cyclohexyl)-1-(4-phenyl-piperazin-1-yl)-propan-1-one (204245-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 18 h / 0 - 20 °C

2: 96 percent / TFA / CHCl₃ / 16 h / Ambient temperature

With trifluoroacetic acid; In dichloromethane; chloroform;

DOI:10.1021/jm9707378

upstream raw materials:

{4-[3-Oxo-3-(4-phenyl-piperazin-1-yl)-propyl]-cyclohexyl}-carbamic acid tert-butyl ester

4-phenyl-1-piperazine

4-nitro-trans-cinnamic acid

3-(trans-4-(tert-butoxycarbonylamino)cyclohexyl)propanoic acid

Downstream raw materials:

1-(4-Phenyl-piperazin-1-yl)-3-[4-(pyrimidin-2-ylamino)-cyclohexyl]-propan-1-one