1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:1402049-30-2
Molecular Formula:C₄₂H₆₄N₂O₅S₂
Molecular Weight:741.113
Hs Code.:

1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

Synonyms:1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of 1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

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Technology Process of 1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

There total 5 articles about 1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1402049-22-2
2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

: 2133-40-6
L-proline methyl ester monohydrochloride

: 1402049-30-2
1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: 2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone; L-proline methyl ester monohydrochloride; With potassium carbonate; In acetonitrile; at 65 ℃; for 18h;

With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1402049-30-2
1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

5.1: potassium carbonate / acetonitrile / 18 h / 65 °C

With hydrogenchloride; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402049-30-2
1-{2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-2-oxo-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

3.1: potassium carbonate / acetonitrile / 18 h / 65 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; acetonitrile;