2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

Base Information

Chemical Name:2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene
CAS No.:213180-70-2
Molecular Formula:C₁₅H₁₇NO₄S₂
Molecular Weight:339.436
Hs Code.:

Synonyms:2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

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Chemical Property of 2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

There total 4 articles about 2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 4455-15-6
ethyl methanesulfonylacetate

: 50609-85-3
(E)-3-methylamino-3-methylthio-1-phenylprop-2-ene-1-thione

: 92802-07-8
ethyl 3-(methylamino)-5-phenylthiophene-2-carboxylate

: 213180-70-2
2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

Guidance literature:: With mercury(II) diacetate; In dichloromethane; Ambient temperature;
DOI:10.1021/jo981043p

Reference yield:

: 30162-68-6
2-methyl-5-phenyl-4-isothiazolin-3-thione

: 213180-70-2
2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate / 48 h / 20 °C

2: NaBH₄ / ethanol / 0.33 h / 20 °C

3: 64 percent / Hg(OAc)2 / CH₂Cl₂ / 3 h / 20 °C

With sodium tetrahydroborate; mercury(II) diacetate; In ethanol; dichloromethane; ethyl acetate; 1: Methylation / 2: Ring cleavage / 3: Cyclization;
DOI:10.1021/jo991884b

Reference yield:

: 4849-59-6
5-phenyl-3-methylthio-1,2-dithiolium iodide

: 213180-70-2
2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene

Guidance literature:: Multi-step reaction with 4 steps

1: iodine / tetrahydrofuran / 0.5 h / -30 - 20 °C

2: ethyl acetate / 48 h / 20 °C

3: NaBH₄ / ethanol / 0.33 h / 20 °C

4: 64 percent / Hg(OAc)2 / CH₂Cl₂ / 3 h / 20 °C

With sodium tetrahydroborate; mercury(II) diacetate; iodine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1: Substitution / 2: Methylation / 3: Ring cleavage / 4: Cyclization;
DOI:10.1021/jo991884b