4455-15-6

Usage

Chemical Properties

Colorless to yellow liquid

InChI:InChI=1/C5H10O4S/c1-3-9-5(6)4-10(2,7)8/h3-4H2,1-2H3

Upstream product

• 61053-62-1 2-methanesulfonyl-acetoacetic acid ethyl ester 
• 64-17-5 ethanol 
• 2516-97-4 2-(methylsulfonyl)acetic acid 
• 3278-34-0 ethyl 2-(ethoxythiocarbonylthio)acetate 
• 67-68-5 dimethyl sulfoxide 
• 20277-69-4 sodium methansulfinate 
• 105-36-2 ethyl bromoacetate 
• 4455-13-4 methylthioacetic acid ethyl ester 
• 100-63-0 phenylhydrazine 

Downstream Products

• 76896-96-3 (E)-ethyl 2-(methylsulfonyl)-3-phenylacrylate 
• 76896-99-6 (E)-3-(3-Fluoro-phenyl)-2-methanesulfonyl-acrylic acid ethyl ester 
• 202196-97-2 (1-Benzyl-1H-indazol-5-yl)-(6-(5-methanesulphonylmethyl-1,2,4-oxadiazol-3-yl)-quinazolin-4-yl)-amine 
• 116622-19-6 ethyl α-(methylsulfonyl)-β-phenylpropionate 
• 116622-16-3 2-methanesulfonyl-4-phenylbutyric acid ethyl ester 
• 847776-02-7 1-benzyl-4-hydroxy-3-(methylsulfonyl)[1,8]naphthyridin-2(1H)-one 
• 1252931-54-6 ethyl 3-(4-methoxyphenyl)-2-(methylsulfonyl)-4-nitrobutanoate 
• 1252931-52-4 ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(methylsulfonyl)-3-p-tolylpropanoate 
• 1257236-76-2 1-methanesulfonyl-cyclopropanecarboxylic acid ethyl ester 
• 75990-31-7 1-Benzoyl-5-benzyliden-4-hydroxy-3-methylsulfonyl-3-pyrrolin-2-on 
• 1356953-28-0 ethyl 3-(4-bromophenylamino)-2-(methylsulfonyl)acrylate 

Relevant academic research and scientific papers

Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO

A new facile method for the synthesis of β-keto sulfones employing xanthates, DMSO, and Fenton's reagent is described. The reaction proceeds under very mild conditions providing a cost-effective straightforward approach to various β-keto sulfones in high yields.

DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS

Compound formula I: wherein: X1 and X2 may be either (a) C and O, (b) N and N, or (c) C and NH, where the dotted bonds represents a double bond in the appropriate location; R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; RN1 is selected from hydrogen and an optionally substituted C1-4 alkyl group; RC1 is selected from an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group; or RN1 and RC1 may together form an optionally substituted C2-4 alkylene group.

PYRIDAZINONE COMPOUNDS

The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Alternative approach to the synthesis of optically active β-keto sulfoxides by furylhydroperoxides enantioselective oxidations

Enantiomerically enriched β-keto sulfoxides are obtainable by an alternative method to the classical reaction of the enantiomerically pure α- sulfinyl anion with esters or by Anderson's synthesis, through Sharpless modified kinetic resolution of racemic β-keto sulfoxides. High e.e.s are achieved by combining asymmetric oxidation and kinetic resolution using furylhydroperoxides as oxidants.