4455-15-6

Basic information

• Product Name: ETHYL METHANESULFONYLACETATE
• Synonyms: ETHYL METHANESULPHONYLACETATE;ETHYL METHANESULFONYLACETATE;ETHYL METHYLSULFONYLACETATE;Ethyl (methylsulphonyl)acetate~Methanesulphonylacetic acid ethyl ester;ethyl (methylsulphonyl)acetate;Ethylmethanesulphonylacetate,97%;Ethyl (methylsulphonyl)acetate 97%;Methanesulphonylacetic acid ethyl ester
• CAS NO: 4455-15-6
• Molecular Formula: C₅H₁₀O₄S
• Molecular Weight: 166.2
• EINECS: 224-702-3
• Product Categories: Acids and Derivatives;Boron, Nitrile, Thio,& TM-Cpds;API intermediates;C2 to C5;Carbonyl Compounds;Esters;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 4455-15-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 111-113 °C0.2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.234 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000839mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1771631
• CAS DataBase Reference: ETHYL METHANESULFONYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL METHANESULFONYLACETATE(4455-15-6)
• EPA Substance Registry System: ETHYL METHANESULFONYLACETATE(4455-15-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 23-24/25-37-26
• WGK Germany: 3
• Hazardous Substances Data: 4455-15-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to yellow liquid

InChI:InChI=1/C5H10O4S/c1-3-9-5(6)4-10(2,7)8/h3-4H2,1-2H3

Upstream product

• 3278-34-0 ethyl 2-(ethoxythiocarbonylthio)acetate 
• 67-68-5 dimethyl sulfoxide 
• 20277-69-4 sodium methansulfinate 
• 105-36-2 ethyl bromoacetate 
• 64-17-5 ethanol 
• 2516-97-4 2-(methylsulfonyl)acetic acid 
• 61053-62-1 2-methanesulfonyl-acetoacetic acid ethyl ester 
• 4455-13-4 methylthioacetic acid ethyl ester 
• 100-63-0 phenylhydrazine 

Downstream Products

• 75990-31-7 1-Benzoyl-5-benzyliden-4-hydroxy-3-methylsulfonyl-3-pyrrolin-2-on 
• 76897-01-3 (E)-2-Methanesulfonyl-3-p-tolyl-acrylic acid ethyl ester 
• 76896-97-4 (E)-3-(4-Chloro-phenyl)-2-methanesulfonyl-acrylic acid ethyl ester 
• 202196-97-2 (1-Benzyl-1H-indazol-5-yl)-(6-(5-methanesulphonylmethyl-1,2,4-oxadiazol-3-yl)-quinazolin-4-yl)-amine 
• 116622-16-3 2-methanesulfonyl-4-phenylbutyric acid ethyl ester 
• 1257236-76-2 1-methanesulfonyl-cyclopropanecarboxylic acid ethyl ester 
• 76896-98-5 (E)-2-Methanesulfonyl-3-(4-methoxy-phenyl)-acrylic acid ethyl ester 
• 76897-00-2 Ethyl β-methylsulfonyl-p-fluorocinnamate 
• 1356953-28-0 ethyl 3-(4-bromophenylamino)-2-(methylsulfonyl)acrylate 
• 1358778-29-6 ethyl 4-(2-acetoxy-6-phenylpyridin-3-yl)-2-methyl-2-(methylsulfonyl)butanoate 
• 1358778-28-5 ethyl 2-methyl-2-(methylsulfonyl)-4-(1-oxido-6-phenylpyridin-3-yl)butanoate 
• 1358778-19-4 ethyl 2-methyl-2-(methylsulfonyl)-4-(6-phenylpyridin-3-yl)butanoate 
• 115666-07-4 EMK 311 
• 1289627-26-4 ethyl 4-[4-(benzyloxy)phenyl]-2-(methylsulfonyl)butanoate 

Relevant articles and documents

Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO

A new facile method for the synthesis of β-keto sulfones employing xanthates, DMSO, and Fenton's reagent is described. The reaction proceeds under very mild conditions providing a cost-effective straightforward approach to various β-keto sulfones in high yields.

PYRIDAZINONE COMPOUNDS

The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Alternative approach to the synthesis of optically active β-keto sulfoxides by furylhydroperoxides enantioselective oxidations

Enantiomerically enriched β-keto sulfoxides are obtainable by an alternative method to the classical reaction of the enantiomerically pure α- sulfinyl anion with esters or by Anderson's synthesis, through Sharpless modified kinetic resolution of racemic β-keto sulfoxides. High e.e.s are achieved by combining asymmetric oxidation and kinetic resolution using furylhydroperoxides as oxidants.