4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

Base Information

Chemical Name:4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate
CAS No.:913957-57-0
Molecular Formula:C₂₀H₁₄ClF₂NO₄
Molecular Weight:405.785
Hs Code.:

Synonyms:4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

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Chemical Property of 4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

Chemical Property:

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Technology Process of 4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

There total 7 articles about 4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₀Cl₂O₄

: 5509-65-9
2,6-difluoroaniline

: 913957-57-0
4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 0.583333h;

Reference yield:

: 2528-00-9
5-Chloromethyl-furan-2-carboxylic acid ethyl ester

: 913957-57-0
4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / nitromethane / 24 h / 20 °C

2.1: boron tribromide / dichloromethane / 0.5 h / -78 - 20 °C

2.2: 0 °C

3.1: sodium hydroxide; ethanol; water / 20 °C

4.1: pyridine / 0.5 h / 80 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

6.1: pyridine / dichloromethane / 0.58 h / 20 °C

With pyridine; aluminum (III) chloride; sodium hydroxide; oxalyl dichloride; ethanol; water; boron tribromide; N,N-dimethyl-formamide; In nitromethane; dichloromethane;

Reference yield:

: 913957-27-4
ethyl 5-{[5-chloro-2-(methyloxy)phenyl]methyl}-2-furancarboxylate

: 913957-57-0
4-chloro-2-[(5-{[(2,6-difluorophenyl)amino]carbonyl}-2-furanyl)methyl]phenylacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 0.5 h / -78 - 20 °C

1.2: 0 °C

2.1: sodium hydroxide; ethanol; water / 20 °C

3.1: pyridine / 0.5 h / 80 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C

5.1: pyridine / dichloromethane / 0.58 h / 20 °C

With pyridine; sodium hydroxide; oxalyl dichloride; ethanol; water; boron tribromide; N,N-dimethyl-formamide; In dichloromethane;