methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

Base Information

Chemical Name:methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate
CAS No.:1421332-97-9
Molecular Formula:C₂₇H₂₄O₃
Molecular Weight:396.486
Hs Code.:

Synonyms:methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

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Technology Process of methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

There total 9 articles about methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1380445-03-3
4-(((1S,2S)-2,3-dihydro-1-hydroxy-2-(1H-inden-2-yl)-1H-inden-2-yl)methyl)benzoic acid

: 74-88-4
methyl iodide

: 1421332-97-9
methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: C₂₆H₂₄O₃

: 18107-18-1
diazomethyl-trimethyl-silane

: 1421332-97-9
methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

Guidance literature:: In methanol; diethyl ether; toluene;
DOI:10.3390/molecules23071503

Reference yield:

: 2,2-dimethoxy-2,3-dihydro-1H-indene

: 1421332-97-9
methyl 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 3 h / -75 - -70 °C

2: potassium tert-butylate / tert-butyl methyl ether; tert-butyl alcohol / 3 h / 20 °C

3: triisobutylaluminum / toluene / 2 h / -12 - 10 °C

4: sodium hydroxide / methanol / 24 h / Reflux

5: Resolution of racemate; Large scale

6: toluene; methanol; diethyl ether

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; triisobutylaluminum; triethylamine; sodium hydroxide; In methanol; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene; tert-butyl alcohol;
DOI:10.3390/molecules23071503