3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan

Base Information

• Chemical Name: 3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan
• CAS No.: 882182-92-5
• Molecular Formula: C₁₈H₁₃F₅O₂
• Molecular Weight: 356.292

Synonyms:3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan

Chemical Property of 3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan

Chemical Property:

Purity/Quality:

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Technology Process of 3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan

There total 2 articles about 3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3,3-difluoro-2-phenyl-cycloprop-1-enyl)-(4-trifluoromethyl-phenyl)-methanone (882182-81-2) + methanol (67-56-1) → 3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan (882182-92-5)

Guidance literature:

With potassium carbonate; at 20 ℃;

DOI:10.1055/s-2006-926266

Reference yield:

3-phenyl-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one (742699-28-1) → 3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan (882182-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaF / bis-(2-methoxy-ethyl) ether / 3 h / 120 °C

2: 89 percent / aq. K₂CO₃ / 20 °C

With potassium carbonate; sodium fluoride; In diethylene glycol dimethyl ether;

DOI:10.1055/s-2006-926266

Reference yield: 86.0%

3,3-difluoro-2-methoxy-2-phenyl-5-(4-trifluoromethyl-phenyl)-2,3-dihydro-furan (882182-92-5) → C17H10F4O2

Guidance literature:

With silica gel; In dichloromethane; at 20 ℃;

DOI:10.1016/j.jfluchem.2006.03.020

upstream raw materials:

(3,3-difluoro-2-phenyl-cycloprop-1-enyl)-(4-trifluoromethyl-phenyl)-methanone

methanol

3-phenyl-1-[4-(trifluoromethyl)phenyl]prop-2-yn-1-one

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