Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

Base Information

Chemical Name:Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate
CAS No.:183014-66-6
Molecular Formula:C₂₀H₁₇F₃N₂O₄
Molecular Weight:406.361
Hs Code.:

Synonyms:Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

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Chemical Property of Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

Chemical Property:

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Technology Process of Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

There total 5 articles about Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 169605-23-6
methyl (R,S)-3-amino-4,4,4-trifluorobutyrate hydrochloride

: 169605-19-0
3-(4-cyanobenzyloxy)benzoic acid

: 183014-66-6
Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In hexane; ethyl acetate;

Reference yield:

: 19438-10-9
methyl 3-hydroxybenzoate

: 183014-66-6
Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 60 °C

2: 1 N LiOH / tetrahydrofuran / 5 h

3: Et₃N, BOP / dimethylformamide

With lithium hydroxide; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00013-8

Reference yield:

: 17201-43-3
4-cyanobenzyl bromide

: 183014-66-6
Methyl N-(3-(4-cyanobenzyloxy)benzoyl)-DL-3-amino-4,4,4-trifluorobutyrate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 60 °C

2: 1 N LiOH / tetrahydrofuran / 5 h

3: Et₃N, BOP / dimethylformamide

With lithium hydroxide; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00013-8