2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

Base Information

Chemical Name:2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol
CAS No.:1174731-69-1
Molecular Formula:C₁₈H₁₃BrCl₂F₃NO
Molecular Weight:467.113
Hs Code.:

Synonyms:2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

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Chemical Property of 2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

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Technology Process of 2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

There total 9 articles about 2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174731-68-0
acetic acid 2-bromo-4-[4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]benzyl ester

: 1174731-69-1
2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1174731-66-8
acetic acid 2-bromo-4-(trimethylsilanylmethyl-carbamoyl)-benzylester

: 1174731-69-1
2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

4: sodium methylate; methanol / 1 h / 20 °C

With Lawessons reagent; methanol; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1556019-48-7
3-bromo-4-formyl-N-[(trimethylsilyl)methyl]benzamide

: 1174731-69-1
2-bromo-4-[4-(3,5-dichlorophenyl )-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylmethanol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

6: sodium methylate; methanol / 1 h / 20 °C

With Lawessons reagent; methanol; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium methylate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;