1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Base Information

Chemical Name:1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline
CAS No.:1315179-69-1
Molecular Formula:C₂₂H₂₀FN₃O₂
Molecular Weight:377.418
Hs Code.:

Synonyms:1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

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Chemical Property of 1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

There total 6 articles about 1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1315180-08-5
1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

: 1315179-69-1
1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: With sodium hydrogencarbonate; triphenylphosphine; palladium diacetate; In ethanol; water; toluene; for 1.75h; Reflux; Inert atmosphere;

Reference yield:

: 123942-11-0
4'-bromo-2 ',5'-difluoroacetophenone

: 1315179-69-1
1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1 h / Reflux

2: ethyl acetate / 4 h / 50 - 60 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 50 - 60 °C

4: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / toluene; ethanol; water / 1.75 h / Reflux; Inert atmosphere

With potassium tert-butylate; sodium hydrogencarbonate; triphenylphosphine; palladium diacetate; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 28314-82-1
4-bromo-2,5-difluorobenzoic acid

: 1315179-69-1
1-(2-aminobenzyl)-7-(3, 5-dimethylisoxazol-4-yl)-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / ethyl acetate / 1.25 h / Reflux

1.2: 8 - 12 °C

1.3: 0.33 h / Cooling

2.1: ethyl acetate / 4 h / 50 - 60 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 50 - 60 °C

4.1: triphenylphosphine; sodium hydrogencarbonate / palladium diacetate / toluene; ethanol; water / 1.75 h / Reflux; Inert atmosphere

With thionyl chloride; potassium tert-butylate; sodium hydrogencarbonate; triphenylphosphine; palladium diacetate; N,N-dimethyl-formamide; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;