1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Base Information

Chemical Name:1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline
CAS No.:1315180-08-5
Molecular Formula:C₁₇H₁₄BrFN₂O
Molecular Weight:361.213
Hs Code.:

Synonyms:1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

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Chemical Property of 1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Chemical Property:

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Technology Process of 1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

There total 5 articles about 1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₅BrF₂N₂O

: 1315180-08-5
1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 1h;

Reference yield:

: 28314-82-1
4-bromo-2,5-difluorobenzoic acid

: 1315180-08-5
1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / ethyl acetate / 1.25 h / Reflux

1.2: 8 - 12 °C

1.3: 0.33 h / Cooling

2.1: ethyl acetate / 4 h / 50 - 60 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 50 - 60 °C

With thionyl chloride; potassium tert-butylate; N,N-dimethyl-formamide; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 123942-11-0
4'-bromo-2 ',5'-difluoroacetophenone

: 1315180-08-5
1-(2-aminobenzyl)-7-bromo-6-fluoro-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1 h / Reflux

2: ethyl acetate / 4 h / 50 - 60 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 50 - 60 °C

With potassium tert-butylate; In ethyl acetate; N,N-dimethyl-formamide;