salinomycin

Base Information

• Chemical Name: salinomycin
• CAS No.: 120330-27-0
• Molecular Formula: C₄₂H₇₀O₁₁
• Molecular Weight: 751.011
• Mol file: 120330-27-0.mol

Synonyms:salinomycin

Chemical Property of salinomycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of salinomycin

There total 132 articles about salinomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

salinomycin (120330-27-0) → salinomycin (53003-10-4,120330-27-0,126574-63-8)

Guidance literature:

With 3 A molecular sieve; trifluoroacetic acid; In dichloromethane; for 0.333333h; Ambient temperature;

DOI:10.1248/cpb.37.1717

Reference yield:

salinomycin SV sodium salt (55721-31-8) → salinomycin (53003-10-4,120330-27-0,126574-63-8)

Guidance literature:

With sulfuric acid; In dichloromethane;

DOI:10.1016/j.bmcl.2012.05.081

Reference yield:

D-Glucose (2280-44-6) → salinomycin (53003-10-4,120330-27-0,126574-63-8)

Guidance literature:

Multi-step reaction with 11 steps

3: 99 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂

4: 96 percent / PPh₃ / benzene / 80 °C

5: 84 percent / n-BuLi / tetrahydrofuran / -78 °C

6: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) oxidation

7: 1.) camphorsulfonic acid, 2.) n-Bu₄NF / 1.) room temperature, 2.) dioxane-THF, 65 deg C

8: 88 percent / H₂ / Lindlar / methanol

9: 1.) DMSO,(COCl)2, Et₃N, 2.) CSA / 1.) CH₂Cl₂, 2.) CH₂Cl₂, room temperature

10: (C₆H₁₁)2NMgBr / methanol / -55 °C

11: DDQ / CH₂Cl₂ / 1.5 h / Ambient temperature; buffer (pH 6.86)

With n-butyllithium; oxalyl dichloride; bis(cyclohexyl)aminomagnesium bromide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; benzene;

DOI:10.1016/S0040-4039(00)80703-0

upstream raw materials:

C₅₇H₈₄O₁₂

C₅₇H₈₄O₁₂

21-episalinomycin

21-epi-20-O-(4-methoxybenzyl)-28-O-benzylsalinomycin

Downstream raw materials:

C₄₈H₇₅NO₁₀

C₄₉H₇₇NO₁₀