21-episalinomycin

Base Information

Chemical Name:21-episalinomycin
CAS No.:126574-63-8
Molecular Formula:C₄₂H₇₀O₁₁
Molecular Weight:751.011
Hs Code.:

Synonyms:21-episalinomycin

Suppliers and Price of 21-episalinomycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 0 raw suppliers

Chemical Property of 21-episalinomycin

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 21-episalinomycin

There total 132 articles about 21-episalinomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 120330-27-0
salinomycin

: 53003-10-4,120330-27-0,126574-63-8
salinomycin

Guidance literature:: With 3 A molecular sieve; trifluoroacetic acid; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.1248/cpb.37.1717

Reference yield:

: 55721-31-8
salinomycin SV sodium salt

: 53003-10-4,120330-27-0,126574-63-8
salinomycin

Guidance literature:: With sulfuric acid; In dichloromethane;
DOI:10.1016/j.bmcl.2012.05.081

Reference yield:

: 2280-44-6
D-Glucose

: 53003-10-4,120330-27-0,126574-63-8
salinomycin

Guidance literature:: Multi-step reaction with 11 steps

3: 99 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂

4: 96 percent / PPh₃ / benzene / 80 °C

5: 84 percent / n-BuLi / tetrahydrofuran / -78 °C

6: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) oxidation

7: 1.) camphorsulfonic acid, 2.) n-Bu₄NF / 1.) room temperature, 2.) dioxane-THF, 65 deg C

8: 88 percent / H₂ / Lindlar / methanol

9: 1.) DMSO,(COCl)2, Et₃N, 2.) CSA / 1.) CH₂Cl₂, 2.) CH₂Cl₂, room temperature

10: (C₆H₁₁)2NMgBr / methanol / -55 °C

11: DDQ / CH₂Cl₂ / 1.5 h / Ambient temperature; buffer (pH 6.86)

With n-butyllithium; oxalyl dichloride; bis(cyclohexyl)aminomagnesium bromide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)80703-0