2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (2S)- (9CI)

Base Information

Chemical Name:2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (2S)- (9CI)
CAS No.:101250-55-9
Molecular Formula:C7H12 Cl N O2
Molecular Weight:177.62868
Hs Code.:
Mol file:101250-55-9.mol

Synonyms:2-Pyrrolidinemethanol,1-(chloroacetyl)-, (S)-;(S)-2-Chloro-1-(2-hydroxymethylpyrrolidin-1-yl)ethanone

Suppliers and Price of 2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (2S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (2S)- (9CI)

Chemical Property:

PSA：40.54000
LogP:0.14640

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (2S)- (9CI)

There total 3 articles about 2-Pyrrolidinemethanol, 1-(chloroacetyl)-, (2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 79-04-9
chloroacetyl chloride

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 101250-55-9
(S)-2-chloro-1-(2-[hydroxymethyl]pyrrolidin-1-yl)ethanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/acs.oprd.7b00169

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 101250-55-9
(S)-2-chloro-1-(2-[hydroxymethyl]pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2015.08.009