Technology Process of 4-p-tolyl-thiophene-2-carboxylic acid
There total 1 articles about 4-p-tolyl-thiophene-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trichlorophosphate / 2 h / 20 °C
1.2: 72 h / 20 °C
2.1: sodium hydroxide; ethanol; water / 2 h / Heating / reflux
2.2: Acidic aqueous solution
With
sodium hydroxide; ethanol; water; trichlorophosphate;
- Guidance literature:
-
4-p-tolyl-thiophene-2-carboxylic acid;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -70 ℃;
for 0.5h;
ethyl iodide;
In
tetrahydrofuran; pentane;
at -70 - 20 ℃;
for 72h;
With
water; ammonium chloride;
In
tetrahydrofuran; pentane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -70 °C
1.2: 72 h / -70 - 20 °C
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
3.1: tetrahydrofuran / 88 h / 3 - 20 °C
4.1: hydrogenchloride / ethanol; isopropyl alcohol / 18 h / 20 °C
5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 1125.11 Torr
With
hydrogenchloride; hydrogen; tert.-butyl lithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; isopropyl alcohol; pentane;
