4-[(trimethylsilyl)methyl]Phenol

Base Information

• Chemical Name: 4-[(trimethylsilyl)methyl]Phenol
• CAS No.: 101224-30-0
• Molecular Formula: C10H16 O Si
• Molecular Weight: 180.322
• DSSTox Substance ID: DTXSID60544955
• Wikidata: Q82422272
• Mol file: 101224-30-0.mol

Synonyms:4-[(trimethylsilyl)methyl]Phenol;101224-30-0;4-(trimethylsilylmethyl)phenol;4-TRIMETHYLSILANYLMETHYL-PHENOL;p-trimethylsilylmethylphenol;SCHEMBL10712863;DTXSID60544955;AKOS006289816

Chemical Property of 4-[(trimethylsilyl)methyl]Phenol

Chemical Property:

• PSA: 20.23000
• LogP: 3.07850
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 180.097041664
• Heavy Atom Count: 12
• Complexity: 131

Purity/Quality:

99% ^*data from raw suppliers

4-TRIMETHYLSILANYLMETHYL-PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)CC1=CC=C(C=C1)O

Technology Process of 4-[(trimethylsilyl)methyl]Phenol

There total 6 articles about 4-[(trimethylsilyl)methyl]Phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(4-methoxy-benzyl)-trimethyl-silane (17988-20-4) → 4-((trimethylsilyl)methyl)phenol (101224-30-0)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 ℃; for 3h;

DOI:10.1002/chem.201404787

Reference yield: 73.0%

4-Fluorophenol (371-41-5) + trimethylsilylmethyllithium (1822-00-0) → 4-((trimethylsilyl)methyl)phenol (101224-30-0)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,2-bis-(diphenylphosphino)ethane; In toluene; pentane; at 80 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02351

Reference yield: 38.0%

4-(trimethylsilylmethyl)phenyl methanesulfonate → 4-((trimethylsilyl)methyl)phenol (101224-30-0)

Guidance literature:

In methanol; Irradiation; Inert atmosphere;

DOI:10.1002/chem.201404787

upstream raw materials:

chloro-trimethyl-silane

p-cresol

(4-methoxy-benzyl)-trimethyl-silane

4-Fluorophenol

Downstream raw materials:

diethyl p-cresyl phosphate

1-methyl-1-phenylethyl alcohol

p-hydroxyphenethyl alcohol

4-tolyl mesylate