N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

Base Information

Chemical Name:N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine
CAS No.:1363359-78-7
Molecular Formula:C₂₂H₂₃ClFN₅O
Molecular Weight:427.909
Hs Code.:

Synonyms:N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

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Chemical Property of N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

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Technology Process of N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

There total 8 articles about N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1363359-77-6
N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)-6-nitroquinazolin-4-amine

: 1363359-78-7
N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

Guidance literature:: With iron; acetic acid; In ethanol; at 30 ℃; for 12h;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363359-78-7
N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 20 °C / Inert atmosphere

6.1: acetic acid; iron / ethanol / 12 h / 30 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; In ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 16499-57-3
7-fluoro-3H-quinazolin-4-one

: 1363359-78-7
N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; sulfuric acid

2.1: thionyl chloride

3.1: isopropyl alcohol

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

4.2: 20 °C / Inert atmosphere

5.1: acetic acid; iron / ethanol / 12 h / 30 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;