N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

Base Information

Chemical Name:N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide
CAS No.:1363358-80-8
Molecular Formula:C₂₅H₂₅ClFN₅O₂
Molecular Weight:481.957
Hs Code.:

Synonyms:N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

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Chemical Property of N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

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Technology Process of N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

There total 9 articles about N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1363359-78-7
N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-4,6-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1363358-80-8
N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

: 1363359-77-6
N-(4-(3-chloro-4-fluorophenyl))-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)-6-nitroquinazolin-4-amine

: 1363358-80-8
N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / ethanol / 12 h / 30 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With iron; acetic acid; triethylamine; In ethanol; dichloromethane;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363358-80-8
N-[4-(3-chloro-4-fluorophenylamino)-7-((5-methyl-5-azaspiro[2.4]heptan-1-yl)methoxy)quinazolin-6-yl]-acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 20 °C / Inert atmosphere

6.1: acetic acid; iron / ethanol / 12 h / 30 °C

7.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; triethylamine; In ethanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol;