(5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one

Base Information

• Chemical Name: (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one
• CAS No.: 1330574-07-6
• Molecular Formula: C₂₃H₂₁NO₃S
• Molecular Weight: 391.491
• Mol file: 1330574-07-6.mol

Synonyms:(5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one

Chemical Property of (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one

There total 5 articles about (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-en-2-one (440084-09-3) + N-(2-bromophenyl)-4-methylbenzenesulfonamide (1024-38-0) → (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one (1330574-07-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 4h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201402913

Reference yield: 80.0%

N-biphenyl-2-yl-4-methylbenzenesulfonamide (24310-30-3) + methyl vinyl ketone (78-94-4,25038-87-3) → (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one (1330574-07-6)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 6h; regioselective reaction;

DOI:10.1002/asia.201100024

Reference yield: 75.0%

4-(2-bromophenyl)but-3-en-2-one (72454-54-7) + 4-methyl-N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide (796061-07-9) → (5-(4-toluenesulfonyl)-5,6-dihydrophenanthridine-6-yl)propan-2-one (1330574-07-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 4h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201402913

upstream raw materials:

N-biphenyl-2-yl-4-methylbenzenesulfonamide

methyl vinyl ketone

2-phenylaniline

p-toluenesulfonyl chloride