4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
• CAS No.: 101130-32-9
• Molecular Formula: C18H15 Cl N2 S
• Molecular Weight: 326.84
• Hs Code.: 2934999090
• Mol file: 101130-32-9.mol

Synonyms:4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

Chemical Property of 4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

Chemical Property:

• Vapor Pressure: 1.16E-06mmHg at 25°C
• Melting Point: 138-140 °C
• Refractive Index: 1.743
• Boiling Point: 413.4°Cat760mmHg
• PKA: 0.87±0.20(Predicted)
• Flash Point: 203.8°C
• PSA: 54.02000
• Density: 1.353g/cm³
• LogP: 5.39390

Purity/Quality:

99% ^*data from raw suppliers

4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

There total 9 articles about 4-CHLORO-2-[2-PHENYLVINYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-styryl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidin-4(3H)-one (101130-10-3) → 4-chloro-2-styryl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine (101130-32-9)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h;

DOI:10.1002/jhet.5570220343

Reference yield:

2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (4815-28-5) → 4-chloro-2-styryl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine (101130-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / conc. aq. HCl / ethanol / 5 h / Heating

2: 77 percent / POCl₃/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h

With hydrogenchloride; N,N-dimethyl-formamide; trichlorophosphate; In ethanol;

DOI:10.1002/jhet.5570220343

Reference yield:

cinnamonitrile (4360-47-8) → 4-chloro-2-styryl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine (101130-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / HCl(g) / dioxane / Ambient temperature

2: 77 percent / POCl₃/DMF / 1.)0-5 deg C, 15-20 min 2.)r.t., 12 h

With hydrogenchloride; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane;

DOI:10.1002/jhet.5570220343

upstream raw materials:

2-styryl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidin-4(3H)-one

cinnamonitrile

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

2-(chloromethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Downstream raw materials:

3-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,2,3a,5-tetraaza-cyclopenta[c]fluorene

2-Methyl-4-((E)-styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

4-((E)-Styryl)-7,8,9,10-tetrahydro-6-thia-1,2,3a,5-tetraaza-cyclopenta[c]fluorene

4-((E)-Styryl)-7,8,9,10-tetrahydro-6-thia-1,3,3a,5-tetraaza-cyclopenta[c]fluorene

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