(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Base Information

Chemical Name:(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1059700-82-1
Molecular Formula:C₂HF₃O₂*C₃₉H₅₀N₄O₅S
Molecular Weight:800.94
Hs Code.:

(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 10 articles about (1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1058166-18-9
8-cyclohexyl-5-((isopropylsulfonyl)carbamoyl)-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

: (1S,4S)-2-isobutyl-2,5-diazabicyclo[2.2.1]heptane bis-trifluoroacetate

: 1059700-82-1
(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

: 1059700-84-3
(1aS,12bR)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 1059700-82-1
(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

: 1059700-84-3
(1aS,12bR)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 0 - 20 °C

2.1: silver carbonate / dichloromethane / 0 - 20 °C / Molecular sieves 4 ?

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 0.25 h

3.2: 4 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C

6.2: 20 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.75 h

7.2: 1 h

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

8.2: 20 °C

9.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 2 h / 20 °C

With lithium hydroxide; sodium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1059700-82-1
(1aR,12bS)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

: 1059700-84-3
(1aS,12bR)-8-cyclohexyl-N-(isopropylsulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-[(1S,4S)-5-isobutyl-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: silver carbonate / dichloromethane / 0 - 20 °C / Molecular sieves 4 ?

2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 0.25 h

2.2: 4 h / 85 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C

5.2: 20 °C

6.1: sodium hydride / dimethyl sulfoxide / 0.75 h

6.2: 1 h

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

7.2: 20 °C

8.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 2 h / 20 °C

With sodium hydroxide; water; sodium hydride; sodium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;