Technology Process of 13-methylcarbamoyl-tridec-12-enoic acid benzyl ester
There total 7 articles about 13-methylcarbamoyl-tridec-12-enoic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 8.50 g / potassium bicarbonate / dimethylformamide / 24 h
2.1: 3.15 g / pyridinium chlorochromate / CH2Cl2 / 1.5 h / 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
3.2: 9.80 g / tetrahydrofuran / 24 h / 0 °C
4.1: 3.95 g / p-toluenesulfonic acid / toluene / 20 °C
5.1: triethylamine; ethyl chloroformate / CHCl3 / 3 h / -5 °C
6.1: 1.85 g / various solvents / -5 - 20 °C
With
chloroformic acid ethyl ester; sodium hydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; chloroform; various solvents; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja003882a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 8.50 g / potassium bicarbonate / dimethylformamide / 24 h
2.1: 3.15 g / pyridinium chlorochromate / CH2Cl2 / 1.5 h / 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
3.2: 9.80 g / tetrahydrofuran / 24 h / 0 °C
4.1: 3.95 g / p-toluenesulfonic acid / toluene / 20 °C
5.1: triethylamine; ethyl chloroformate / CHCl3 / 3 h / -5 °C
6.1: 1.85 g / various solvents / -5 - 20 °C
With
chloroformic acid ethyl ester; sodium hydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; chloroform; various solvents; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja003882a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 3.15 g / pyridinium chlorochromate / CH2Cl2 / 1.5 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
2.2: 9.80 g / tetrahydrofuran / 24 h / 0 °C
3.1: 3.95 g / p-toluenesulfonic acid / toluene / 20 °C
4.1: triethylamine; ethyl chloroformate / CHCl3 / 3 h / -5 °C
5.1: 1.85 g / various solvents / -5 - 20 °C
With
chloroformic acid ethyl ester; sodium hydride; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; chloroform; various solvents; toluene;
DOI:10.1021/ja003882a
