2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid

Base Information

• Chemical Name: 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid
• CAS No.: 108446-70-4
• Molecular Formula: C₂₀H₁₆N₂O₅
• Molecular Weight: 364.357
• Mol file: 108446-70-4.mol

Synonyms:2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid

Chemical Property of 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid

There total 4 articles about 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

malonic acid (141-82-2) + 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde (36640-42-3) → 3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid (108446-75-9) + 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid (108446-70-4)

Guidance literature:

With piperidine; In pyridine; at 95 - 100 ℃;

Reference yield: 77.8%

2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester (108446-88-4) → 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid (108446-70-4)

Guidance literature:

With sodium hydroxide; In methanol; water; for 2h; Heating;

Reference yield:

4-methoxyacetophenone phenylhydrazone (24310-46-1) → 2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid (108446-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.5 percent / POCl₃

2: 82.8 percent / piperidine

3: 77.8 percent / NaOH / methanol; H₂O / 2 h / Heating

With piperidine; sodium hydroxide; trichlorophosphate; In methanol; water;

upstream raw materials:

2-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester

malonic acid

3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde

4-methoxyacetophenone phenylhydrazone

Downstream raw materials:

3-[3-(4-Methoxy-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionic acid

3-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid