N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

Base Information

Chemical Name:N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide
CAS No.:1453114-75-4
Molecular Formula:C₂₃H₂₆N₄O₂
Molecular Weight:390.485
Hs Code.:

Synonyms:N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

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Chemical Property of N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

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Technology Process of N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

There total 7 articles about N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1453114-71-0
1-[(2S)-N-benzylpyrrolidin-2-yl]-N-methylidenemethanamine

: 119-51-7
1-phenyl-1,2-propanedione 2-oxime

: 1453114-75-4
N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

Guidance literature:: In ethanol; for 3h; Reflux;
DOI:10.1016/j.tetasy.2013.07.013

Reference yield:

: 31795-93-4
N-benzyl-L-proline

: 1453114-75-4
N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 8.17 h / Reflux

3.1: hydrazine / ethanol / 2 h / Reflux

3.2: 0.5 h / Heating

4.1: methanol / 20 °C

5.1: ethanol / 3 h / Reflux

With lithium aluminium tetrahydride; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.tetasy.2013.07.013

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1453114-75-4
N-phenyl-1-{[(2S)-N-benzylpyrrolidin-2-yl]methyl}-5-methyl-1H-imidazole-4-carboxamide 3-oxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / isopropyl alcohol

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 8.17 h / Reflux

4.1: hydrazine / ethanol / 2 h / Reflux

4.2: 0.5 h / Heating

5.1: methanol / 20 °C

6.1: ethanol / 3 h / Reflux

With lithium aluminium tetrahydride; triphenylphosphine; potassium hydroxide; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; isopropyl alcohol;
DOI:10.1016/j.tetasy.2013.07.013