3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

Base Information

Chemical Name:3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide
CAS No.:1403881-27-5
Molecular Formula:C₂₀H₁₄BrF₅N₂O₄
Molecular Weight:521.238
Hs Code.:

Synonyms:3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

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Chemical Property of 3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

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Technology Process of 3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

There total 10 articles about 3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403881-26-4
3-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(3-carbamoyl-2,4-difluorophenoxy)propyl acetate

: 1403881-27-5
3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.11.002

Reference yield:

: 2,6-difluoro-3-methoxybenzamide

: 1403881-27-5
3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

3: potassium carbonate; methanol / 1 h / 20 °C

With methanol; boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.11.002

Reference yield:

: 3-[4-(4-trifluoromethyl-phenyl)-oxazol-2-yl]-propan-1-ol

: 1403881-27-5
3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2: N-Bromosuccinimide; acetic acid / 2 h / 20 °C

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

5: potassium carbonate; methanol / 1 h / 20 °C

With methanol; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; triethylamine; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.11.002