3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

Base Information

Chemical Name:3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide
CAS No.:1403881-52-6
Molecular Formula:C₂₂H₁₉BrF₅N₃O₃
Molecular Weight:548.307
Hs Code.:

Synonyms:3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

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Chemical Property of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

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Technology Process of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

There total 12 articles about 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1403884-47-8
3-(3-bromo-1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)propoxy)-2,6-difluorobenzamide

: 124-40-3
dimethyl amine

: 1403881-52-6
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield:

: 1403881-27-5
3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide

: 124-40-3
dimethyl amine

: 1403881-52-6
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

Guidance literature:: 3-[1-[5-bromo-4-[4-(trifluoromethyl)phenyl]oxazol-2-yl]-3-hydroxy-propoxy]-2,6-difluoro-benzamide; With phosphorus tribromide; In toluene; for 0.5h; Reflux;

dimethyl amine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2013.11.002 DOI:10.1016/j.bmcl.2013.11.002

Reference yield:

: 2,6-difluoro-3-methoxybenzamide

: 1403881-52-6
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-3-(dimethylamino)propoxy)-2,6-difluoro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

3.1: potassium carbonate; methanol / 1 h / 20 °C

4.1: phosphorus tribromide / toluene / 0.5 h / Reflux

4.2: 16 h / 20 °C

With methanol; boron tribromide; phosphorus tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.11.002