Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Base Information

Chemical Name:Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside
CAS No.:303127-94-8
Molecular Formula:C₂₈H₃₈Cl₃NO₆Si
Molecular Weight:619.057
Hs Code.:

Synonyms:Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

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Chemical Property of Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

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Technology Process of Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

There total 9 articles about Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1053708-33-0
N-((2R,3R,4R,5R,6R)-2,5-Bis-benzyloxy-4-hydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl)-2,2,2-trichloro-acetamide

: 303127-94-8
Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.666667h;
DOI:10.1039/b002835p

Reference yield:

: 100-39-0
benzyl bromide

: 303127-94-8
Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 81 percent / TBAI / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: methanol / 48 h

3.1: 2.45 g / imidazole / dimethylformamide / 0.67 h / 0 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Etherification / 2.1: Substitution / 3.1: Substitution;
DOI:10.1039/b002835p

Reference yield:

: N-((2R,3R,4R,5S,6R)-2-Benzyloxy-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl)-2,2,2-trichloro-acetamide

: 303127-94-8
Benzyl 4-O-benzyl-6-O-(tert-butyldimethylsilyl)-2-deoxy-2-trichloroacetamido-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2.79 g / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

2.1: 98 percent / pyridine / CH₂Cl₂ / 2 h / -15 - 0 °C

3.1: 65 percent / NaNO₂ / dimethylformamide / 1.5 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

4.2: 81 percent / TBAI / tetrahydrofuran / 5 h / 0 - 20 °C

5.1: methanol / 48 h

6.1: 2.45 g / imidazole / dimethylformamide / 0.67 h / 0 °C

With pyridine; 1H-imidazole; sodium hydride; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Substitution / 3.1: Substitution / 4.1: Metallation / 4.2: Etherification / 5.1: Substitution / 6.1: Substitution;
DOI:10.1039/b002835p