(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

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Chemical Name:(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine
CAS No.:1352232-88-2
Molecular Formula:C₂₇H₃₀N₆O₄S₂
Molecular Weight:566.705
Hs Code.:

Synonyms:(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

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Chemical Property of (3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

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Technology Process of (3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

There total 19 articles about (3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 916176-50-6
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1352412-35-1
(1-[2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl]cyclopropyl)(imino)methyl-lambda6-sulfanone

: 1352232-88-2
(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 90 ℃; for 6h; Inert atmosphere;

Reference yield: 80.0%

: 1310556-95-6
{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}boronic acid

: [1-[2-chloro-6-[(3R)-3-methylmorpholin-4-yl]-pyrimidin-4-yl]cyclopropyl](imino)methyloxo-λ6-sulfane hydrochloride

: 1352232-88-2
(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; water;
DOI:10.1021/acs.oprd.9b00075

Reference yield:

: 6299-85-0
2,6-dichloropyrimidine-4-carboxylic acid methyl ester

: 1352232-88-2
(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 18.83 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1.58 h / 25 °C

4: lithium iodide / 1,4-dioxane / 1 h / 107 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

6: sodium periodate / ethyl acetate; water; methanol / 16 h / 20 °C

7: magnesium oxide; [bis(acetoxy)iodo]benzene / dirhodium tetraacetate / dichloromethane / 96 h / 20 °C

8: sodium hydroxide / tetraoctyl ammonium bromide / 2-methyltetrahydrofuran / 48 h / 20 °C / Inert atmosphere

9: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 6 h / 90 °C / Inert atmosphere

With sodium periodate; lithium borohydride; [bis(acetoxy)iodo]benzene; magnesium oxide; sodium carbonate; triethylamine; sodium hydroxide; lithium iodide; bis-triphenylphosphine-palladium(II) chloride; dirhodium tetraacetate; tetraoctyl ammonium bromide; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;