(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

Base Information

Chemical Name:(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol
CAS No.:596095-57-7
Molecular Formula:C₂₂H₃₂O₄
Molecular Weight:360.494
Hs Code.:

Synonyms:(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

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Chemical Property of (2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

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Technology Process of (2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

There total 8 articles about (2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 596095-56-6
(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dienoic acid methyl ester

: 596095-57-7
(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; at -78 ℃;
DOI:10.1016/S0040-4039(03)01173-0

Reference yield:

: 88406-01-3
2,3-O-isopropylidene-1-C-<(1R)-1-methylprop-2-enyl>-D-erythro-glycerol

: 596095-57-7
(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 66 percent / NaH; TBAI / dimethylformamide / 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 80 percent / PPh₃ / -25 °C

3.1: 70 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

4.1: 94 percent / DIBAL-H / hexane / -78 °C

5.1: 85 percent / DMP / CH₂Cl₂ / 0 °C

6.1: 65 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

7.1: 88 percent / DIBAL-H / hexane / -78 °C

With n-butyllithium; phthalic acid dimethyl ester; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; ozone; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 6.1: Wittig reaction;
DOI:10.1016/S0040-4039(03)01173-0

Reference yield:

: 109121-41-7
(R)-4-((1S,2R)-1-benzyloxy-2-methylbut-3-enyl)-2,2-dimethyl-[1,3]dioxolane

: 596095-57-7
(2E,4E)-(6R,7S)-7-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4,6-trimethyl-hepta-2,4-dien-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: 80 percent / PPh₃ / -25 °C

2.1: 70 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

3.1: 94 percent / DIBAL-H / hexane / -78 °C

4.1: 85 percent / DMP / CH₂Cl₂ / 0 °C

5.1: 65 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

6.1: 88 percent / DIBAL-H / hexane / -78 °C

With n-butyllithium; phthalic acid dimethyl ester; diisobutylaluminium hydride; ozone; In tetrahydrofuran; hexane; dichloromethane; 5.1: Wittig reaction;
DOI:10.1016/S0040-4039(03)01173-0