2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

Base Information

Chemical Name:2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide
CAS No.:1439905-97-1
Molecular Formula:C₁₈H₂₂F₂N₆O
Molecular Weight:376.409
Hs Code.:

Synonyms:2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

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Chemical Property of 2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

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Technology Process of 2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

There total 9 articles about 2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 227449-48-1
2-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-4-(m-tolylamino)pyrimidin-5-carboxamide

: (1S,2S)-3,3-difluorocyclohexane-1,2-diamine ditrifluoroacetate

: 1439905-97-1
2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 3h;

Reference yield:

: 1374973-16-6
(1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate

: 1439905-97-1
2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate

3: 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 90 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; ethyl acetate;

Reference yield:

: 1374973-14-4
(1R,6S)-6-amino-2,2-difluorocyclohexanol

: 1439905-97-1
2-(((1S,2S)-2-amino-3,3-difluorocyclohexyl)amino)-4-(m-tolylamino)pyrimidin-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran

2: pyridine / dichloromethane / 0.17 h / Cooling with ice

3: sodium azide / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

4: palladium 10% on activated carbon; hydrogen / ethyl acetate

5: 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 90 °C

With pyridine; sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate;