Technology Process of 2-((3-fluorophenoxy)methyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
There total 13 articles about 2-((3-fluorophenoxy)methyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere
2.1: ammonia / methanol / 24 h / 100 °C / Sealed vessel
3.1: hydrogen bromide; acetic acid / 16 h / 60 °C
4.1: trichlorophosphate / 8 h / 100 °C
5.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 60 °C
6.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethanol / 1 h / 150 °C / Microwave synthesizer
7.1: ozone / dichloromethane; methanol / 0.5 h / -78 °C
7.2: 0.17 h / 0 °C
8.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 20 °C
With
di-isopropyl azodicarboxylate; potassium tert-butylate; ammonia; hydrogen bromide; caesium carbonate; ozone; acetic acid; trichlorophosphate;
bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium(0); 2,6-di-tert-butyl-4-methyl-phenol;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: thionyl chloride / 5 h / 80 °C / Industry scale
2.1: 1 h / 20 °C / Industry scale
3.1: 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere
4.1: ammonia / methanol / 24 h / 100 °C / Sealed vessel
5.1: hydrogen bromide; acetic acid / 16 h / 60 °C
6.1: trichlorophosphate / 8 h / 100 °C
7.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 60 °C
8.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethanol / 1 h / 150 °C / Microwave synthesizer
9.1: ozone / dichloromethane; methanol / 0.5 h / -78 °C
9.2: 0.17 h / 0 °C
10.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 20 °C
With
thionyl chloride; di-isopropyl azodicarboxylate; potassium tert-butylate; ammonia; hydrogen bromide; caesium carbonate; ozone; acetic acid; trichlorophosphate;
bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium(0); 2,6-di-tert-butyl-4-methyl-phenol;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
