Technology Process of 7,8,9-trimethoxy-6-(4-methoxyphenyl)pyrimido[5,4-c]isoquinolin-2-amine
There total 5 articles about 7,8,9-trimethoxy-6-(4-methoxyphenyl)pyrimido[5,4-c]isoquinolin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluorormethanesulfonic acid;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 16h;
DOI:10.3762/bjoc.8.220
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dichloromethane / 6 h / 20 °C
2: sodium methylate / methanol / Reflux
3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 3000.3 Torr
4: trifluorormethanesulfonic acid / N,N-dimethyl-formamide / 16 h / 120 °C
With
trifluorormethanesulfonic acid; palladium 10% on activated carbon; hydrogen; sodium methylate;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
4: |Pictet-Spengler Synthesis;
DOI:10.3762/bjoc.8.220
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium methylate / methanol / Reflux
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 3000.3 Torr
3: trifluorormethanesulfonic acid / N,N-dimethyl-formamide / 16 h / 120 °C
With
trifluorormethanesulfonic acid; palladium 10% on activated carbon; hydrogen; sodium methylate;
In
methanol; N,N-dimethyl-formamide;
3: |Pictet-Spengler Synthesis;
DOI:10.3762/bjoc.8.220
